The genomes of all organisms abound with various cis-regulatory elements, which control
gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and …

The steroid hormone ecdysone regulates insect development via its nuclear receptor (the
EcR protein), which functions as a ligand-dependent transcription factor. The EcR regulates …

Ecdysone signaling in Drosophila remains a popular model for investigating the
mechanisms of steroid action in eukaryotes. The ecdysone receptor EcR can effectively bind …

The rate of carbohydrate metabolism is tightly coordinated with developmental transitions in
Drosophila, and fluctuates depending on the requirements of a particular developmental …

Abstract The Polycomb group (PcG) and Trithorax group (TrxG) proteins are key epigenetic
regulators controlling the silenced and active states of genes in multicellular organisms …

Background Epigenetic memory plays a critical role in the establishment and maintenance
of cell identities in multicellular organisms. Polycomb and trithorax group (PcG and TrxG) …

The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor
function that depends on the inclusion of one of the two mutually exclusive exons (MXE) …

For many years it was believed that promoter-proximal RNA-polymerase II (Pol II) pausing
manages the transcription of genes in Drosophila development by controlling …

Proximity-dependent biotin labelling revealed undescribed participants of the ecdysone
response in Drosophila. Two labelling enzymes (BioID2 and APEX2) were fused to EcR or …

Histone-modifying and remodeling complexes are considered the main coregulators that
affect transcription by changing the chromatin structure. Coordinated action by these …