It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Our physiology and behavior follow precise daily programs that adapt us to the alternating
opportunities and challenges of day and night. Under experimental isolation, these rhythms …

A comprehensive characterization of regulatory elements in the chicken genome across
tissues will have substantial impacts on both fundamental and applied research. Here, we …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

In sepsis, limited food intake and increased energy expenditure induce a starvation
response, which is compromised by a quick decline in the expression of hepatic PPARα, a …

Despite recent advances in single-cell genomics, the lack of maps for single-cell candidate
cis-regulatory elements (cCREs) in non-mammal species has limited our exploration of …

Background. Literature and data mining found abnormal induction of chemokine (C‐X‐C
motif) ligand 1 (CXCL1) and CXCL8 and down‐regulation of CXCL2 in inflammatory liver …

Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating
metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis …

Nuclear receptor corepressors (NCoRs) function in multiprotein complexes containing
histone deacetylase 3 (HDAC3) to alter transcriptional output primarily through repressive …

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent
circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis …