The common mutation BRAFV600 in primary melanomas activates the mitogen-activated
protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

The colon tumor microenvironment is becoming increasingly recognized as a complex but
central player in the development of many cancers. Previously, we identified an oncogenic …

As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that
described how we intended to replicate selected experiments from 29 high-impact …

The process of coordinating between the same or multiple types of cells to jointly execute
various instructions in a controlled and carefully regulated environment is a very appealing …

Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis.
Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues …

Cripto-1 is a member of the EGF-CFC/FRL1/Cryptic family and is involved in embryonic
development and carcinogenesis. We designed a novel anti-Cripto-1 artificial antibody and …

Compared with traditional chemotherapeutic drugs, targeted therapeutic medicine has the
advantages of high efficacy and less toxic side effects. However, in clinical practice for …

The introduction of BRAF/MEK inhibitors into melanoma therapy revolutionized treatment
because of their effects on patient survival. However, not all cases respond to these drugs …