Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus
L Shan, X Xu, J Zhang, P Cai, H Gao, Y Lu, J Shi… - Molecular …, 2021 - Springer
Background Neovasculogenesis is characteristic of herniated lumbar discs, in which
extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative …
extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative …
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents
K Sishtla, N Lambert-Cheatham, B Lee, DH Han… - Cell chemical …, 2022 - cell.com
Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple
diseases. In particular, it is a mediator of neovascularization in the eye and thus an …
diseases. In particular, it is a mediator of neovascularization in the eye and thus an …
[HTML][HTML] Measurement of mitochondrial respiration in the murine retina using a Seahorse extracellular flux analyzer
Mitochondrial metabolism is a critical mechanism that is deregulated in numerous retinal
diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure …
diseases. Here, we elaborate a protocol to quantify oxygen consumption rate as a measure …
[PDF][PDF] Heme-induced ferroptosis promotes human lumbar disc degeneration analyzed by MALDI-TOF MS
L Shan, X Xu, J Zhang, P Cai, H Gao, Y Lu, J Shi… - 2021 - scholar.archive.org
Background Neovasculogenesis is a characteristic of degenerative lumbar discs, which
makes extruded tissues exposed to heme-iron cytotoxicity (increased oxidative stress by …
makes extruded tissues exposed to heme-iron cytotoxicity (increased oxidative stress by …