Phosphoinositides are a family of membrane lipids essential for many biological and
pathological processes. Due to the existence of multiple phosphoinositide regioisomers and …

The field of phosphoinositide signaling has expanded significantly in recent years.
Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal …

Phosphatidylinositol 5‐phosphate 4‐kinases (PI5P4K), also known as type II PIPKs or
PIPKIIs, convert the lipid second messenger PI5P to PI (4, 5) P2. The PI5P4K family consists …

Phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) are
low-abundance phosphoinositides crucial for key cellular events such as endosomal …

While organelles are individual compartments with specialized functions, it is becoming
clear that organellar communication is essential for maintaining cellular homeostasis. This …

Triazolium cyclodextrin click cluster (+ CCC) is an ideal scaffold to specifically bind
phosphoinositides (PIPs) via multivalent electrostatic interaction. A new enrichment material …

Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P2] hydrolysis by phospholipase C (PLC) is
a conserved mechanism of signalling. Given the low abundance of PI (4, 5) P2, its hydrolysis …

Myotubularin or MTM1 is a lipid phosphatase that regulates vesicular trafficking in the cell.
The MTM1 gene is mutated in a severe form of muscular disease, X-linked myotubular …

The activation of phospholipase Cβ (PLCβ) is an essential step during sensory transduction
in Drosophila photoreceptors. PLCβ activity results in the hydrolysis of the membrane lipid …

The ability to co-ordinate function between multiple cells is a critical requirement for multi-
cellularity. This co-ordination is mediated by hormones or growth factors, molecules …