Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

Integrins are cell surface receptors that form the link between extracellular matrix molecules
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …

Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the
most frequent and troublesome complications of diabetes mellitus. It is the major reason for …

Peripheral neuropathy afflicts 60% of all diabetic patients. Underlying the clinical disorder is
the loss or degeneration of neurons, Schwann cells, and neuronal fibers. This degenerative …

Insulin and insulin-like growth factors (IGFs) maintain vital neuronal functions. Absolute or
functional deficiencies of insulin or IGF-I may contribute to neuronal and vascular …

We compared the distribution of the α‐subunit mRNAs of voltage‐gated sodium channels
Nav1. 1–1.3 and Nav1. 6–1.9 and a related channel, Nax, in histochemically identified …

Complications induced by the chemotherapeutic agent cisplatin, such as neuropathy and
cachexia, occur frequently, are often dose limiting, and have an impact on quality of life and …

Diabetic neuropathic pain imposes a huge burden on individuals and society, and
represents a major public health problem. Despite aggressive efforts, diabetic neuropathic …

Pain, one of the most important problems in the field of medicine and public health, has
great research significance. Opioids are still the main drugs to relieve pain now. However, its …

Insulin-like growth factor 1 (IGF-1) is implicated in the nociceptive (pain) sensitivity of primary
afferent neurons. We found that the IGF-1 receptor (IGF-1R) functionally stimulated voltage …