Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Synonymous codon changes, which do not alter protein sequence, were previously thought
to have no functional consequence. Although this concept has been overturned in recent …

Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …

Although previous studies demonstrated circular RNAs (circRNAs) does not exclusively
comprise mRNA exons, no study has extensively explored their internal structure. By …

Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical
samples remains challenging, especially for super-enhancers. Enhancer activities can be …

The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved
proteins that are involved in gene-expression regulation; however, their in vivo targets and …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
cystic fibrosis (CF), and the CFTR-W1282X nonsense mutation causes a severe form of CF …

Glioma is the most common form of malignant primary brain tumours in adults. Their highly
invasive nature makes the disease incurable to date, emphasizing the importance of better …

Defects at the level of the pre-mRNA splicing process represent a major cause of human
disease. Approximately 15–50% of all human disease mutations have been shown to alter …