Tumour-suppressor genes are indispensable for the maintenance of genomic integrity.
Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have …

Rheumatic diseases can be divided in two groups, autoinflammatory and autoimmune
disorders. The clinical presentation of both types of diseases overlap, but the pathological …

We recently identified ten novel SLE susceptibility loci in Asians and uncovered several
additional suggestive loci requiring further validation. This study aimed to replicate five of …

Owing to safety concerns or insufficient efficacy, few drug candidates are approved for
marketing. Drugs already on the market may be withdrawn due to adverse effects (AEs) …

The repertoire of autoantibodies found in cancer patients partly overlaps with that typical of
patients with autoimmune diseases. Beside the biochemical and immunological properties …

Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ
systems with diverse presentation, primarily affecting women of reproductive age. Various …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple
organs and tissues, which is characterized by the presence of excessive anti-nuclear …

BACKGROUND: The majority of ovarian cancer cases are diagnosed at an advanced stage
with poor prognosis. This study evaluates autoantibodies against tumor antigens to identify …

The tumor suppressor p53 has been shown to play a central role in tumor suppression by
inducing apoptosis, cell cycle arrest, senescence, and DNA repair. In addition, recent …

Viral and cellular double-stranded RNA (dsRNA) is recognized by cytosolic innate immune
sensors, including RIG-I-like receptors. Some cytoplasmic dsRNA is commonly present in …