Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

ε-N-acetylation of lysine residues (Kac) is one of the most abundant post-translation
modifications (PTMs) in the human proteome. In the nucleus, acetylation of histones has …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

Interaction of pathogens with cells of the immune system results in activation of inflammatory
gene expression. This response, although vital for immune defence, is frequently deleterious …

Epigenetic mechanisms of gene regulation have a profound role in normal development and
disease processes. An integral part of this mechanism occurs through lysine acetylation of …

The acetylation of histone lysine is central to providing the dynamic regulation of chromatin-
based gene transcription. The bromodomain (BRD), which is the conserved structural …

Post-translational modifications of the nucleosomal histone proteins orchestrate chromatin
organization and gene expression in normal and cancer cells. Among them, the acetylation …

Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse -
Shang - 2009 - Developmental Dynamics - Wiley Online Library Skip to Article Content Skip to …

Retroviral integrase (IN) proteins catalyze the permanent integration of proviral genomes
into host DNA with the help of cellular cofactors. Lens epithelium-derived growth factor …

Histone lysine acetylation is a key component of epigenetic regulation of gene transcription.
Bromodomains, found in histone acetyl transferases and other chromatin-associated …