[HTML][HTML] Review on recent development of quinoline for anticancer activities

M Ilakiyalakshmi, AA Napoleon - Arabian Journal of Chemistry, 2022 - Elsevier
Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

V Yadav, J Reang, V Sharma, J Majeed… - Chemical Biology & …, 2022 - Wiley Online Library
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …

An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds

O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …

Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening …

RA Kardile, AP Sarkate, DK Lokwani, SV Tiwari… - European Journal of …, 2023 - Elsevier
Here in, we report the design, synthesis and in vitro anticancer activity of a novel series of 24
quinoline analogues of substituted amide and sulphonamide derivatives. The anticancer …

Discovery of new pyrimido [5, 4-c] quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies

RA Mekheimer, SMR Allam, MA Al-Sheikh… - Bioorganic …, 2022 - Elsevier
A novel series of pyrimido [5, 4-c] quinoline derivatives variously substituted at positions 2
and 5 have been synthesized, in good to excellent yields, via rapid base-catalyzed …

Overcoming C797S mutation: The challenges and prospects of the fourth-generation EGFR-TKIs

HY Zhao, XX Xi, M Xin, SQ Zhang - Bioorganic Chemistry, 2022 - Elsevier
The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)
have accomplished impressive clinical achievements in the treatment of non-small-cell lung …

Design and synthesis of novel Thiazolo [5, 4-b] pyridine derivatives as potent and selective EGFR-TK inhibitors targeting resistance mutations in non-small cell lung …

AS Borude, SR Deshmukh, SV Tiwari, SH Kumar… - European Journal of …, 2024 - Elsevier
A novel series of substituted thiazolo [5, 4-b] pyridine analogues were rationally designed
and synthesized via a multi-step synthetic pathway, including Suzuki cross-coupling …

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

MM Elbadawi, WM Eldehna… - Journal of Enzyme …, 2022 - Taylor & Francis
In this study, different assortments of 2-arylquinolines and 2, 6-diarylquinolines have been
developed. Recently, we have developed a new series of 6, 7-dimethoxy-4-alkoxy-2 …

Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR …

KS Karnik, AP Sarkate, SV Tiwari, R Azad… - Bioorganic Chemistry, 2021 - Elsevier
Two different schemes of novel substituted quinoline derivatives were designed and
synthesized via simple reaction steps and conditions. A comparative molecular docking …

Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer

RD Keflee, KH Leong, S Ogawa, J Bignon… - Biochemical …, 2022 - Elsevier
The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC)
has been vastly studied over the last decade. This has led to the rapid development of many …