Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

INTRODUCTION In cellular immunity, cytotoxic T lymphocytes (CTLs) and natural killer (NK)
cells use perforin to deliver serine protease granzymes into target cells to kill them …

In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Failure of cytotoxic T lymphocytes (CTLs) or natural killer (NK) cells to kill target cells by
perforin (Prf)/granzyme (Gzm)-induced apoptosis causes severe immune dysregulation. In …

This review aims to highlight the proteases required for regulated cell death mechanisms in
animals and plants. The aim is to be incisive, and not inclusive of all the animal proteases …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …