Acute cerebellar inflammation and related ataxia: mechanisms and pathophysiology

MSA Parvez, G Ohtsuki - Brain sciences, 2022 - mdpi.com
The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …

Synergistic excitability plasticity in cerebellar functioning

G Ohtsuki, M Shishikura, A Ozaki - The FEBS Journal, 2020 - Wiley Online Library
The cerebellum, a universal processor for sensory acquisition and internal models, and its
association with synaptic and nonsynaptic plasticity have been envisioned as the biological …

Analgesic dorsal root ganglionic field stimulation blocks conduction of afferent impulse trains selectively in nociceptive sensory afferents

D Chao, Z Zhang, CM Mecca, QH Hogan, B Pan - Pain, 2020 - journals.lww.com
Increased excitability of primary sensory neurons after peripheral nerve injury may cause
hyperalgesia and allodynia. Dorsal root ganglion field stimulation (GFS) is effective in …

Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum

TF Lin, SE Busch, C Hansel - Nature Communications, 2024 - nature.com
Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …

Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination

M Watanave, N Takahashi, N Hosoi… - Proceedings of the …, 2022 - National Acad Sciences
The cerebellum, the site where protein kinase C (PKC) was first discovered, contains the
highest amount of PKC in the central nervous system, with PKCγ being the major isoform …

[HTML][HTML] Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

Y Yamawaki, Y Wada, S Matsui, G Ohtsuki - Current Research in …, 2022 - Elsevier
Lipopolysaccharide (LPS), an outer component of Gram-negative bacteria, induces a strong
response of innate immunity via microglia, which triggers a modulation of the intrinsic …

Immune-triggered forms of plasticity across brain regions

M Hikosaka, T Kawano, Y Wada, T Maeda… - Frontiers in Cellular …, 2022 - frontiersin.org
Immune cells play numerous roles in the host defense against the invasion of
microorganisms and pathogens, which induces the release of inflammatory mediators (eg …

Psychosis symptoms following aberrant immunity in the brain

A Ozaki, Y Yamawaki, G Ohtsuki - Neural Regeneration Research, 2021 - journals.lww.com
Neuroinflammation in the brain is thought related to the emergence of various psychoses,
although the identifying regional significance, the involvement of immune-cells and …

[PDF][PDF] Why is synaptic plasticity not enough

C Hansel, JF Disterhoft - Neurobiology of Learning and Memory, 2020 - academia.edu
The claim that synaptic plasticity is not the only cellular mechanism underlying learning, or
that it is not involved in learning at all, is not new. It has been pointed out that stimulus timing …

Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning

A Geminiani, C Casellato, HJ Boele… - PLOS Computational …, 2024 - journals.plos.org
According to the motor learning theory by Albus and Ito, synaptic depression at the parallel
fibre to Purkinje cells synapse (pf-PC) is the main substrate responsible for learning …