Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …

Inflammatory molecules and exosomes are crucial for signal transduction between tumor-
associated macrophages and tumor cells. IL-6, a key inflammatory molecule secreted by M2 …

Abstract Rationale: Tumor-associated macrophages (TAMs), generally displaying the pro-
tumor M2-like phenotype, strongly influence the progression of colorectal cancer (CRC) via …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Despite
significant progress that has been made in therapies against CRC over the past decades …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Simple Summary 5-Fluorouracil (5-FU), in combination with various therapeutic agents, is
the main strategy for patients with high risk of stage 2, and advanced stages of, human …

Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group
of immature cells derived from bone marrow and play critical immunosuppressive functions …

Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …