BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Covering: 2011. Previous review: Nat. Prod. Rep., 2012, 29, 144–222. This review covers
the literature published in 2011 for marine natural products, with 870 citations (558 for the …

Covering: 2002. Previous review: Nat. Prod. Rep., 2003, 20, 1 This review covers the
literature published in 2002 for marine natural products, with 579 citations (413 for the …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Marine sponges are productive sources of bioactive secondary metabolites with over 200
new compounds isolated each year, contributing 23% of approved marine drugs so far. This …

Cancer is one of the greatest challenges of the modern medicine. Although much effort has
been made in the development of novel cancer therapeutics, it still remains one of the most …

Eleven years after the start of a new millennium characterized by amazing scientific
development, the cure for cancer remains a major challenge for humanity. In this regard …

Over the past seven decades, particularly since the discovery of the first marine-derived
nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya …

Covering: up to the end of 2014 Polyketides represent an important class of secondary
metabolites that interact with biological targets connected to a variety of disease-associated …

Covering: 2000 up to 2016 Peloruside A, a macrocyclic secondary metabolite from a New
Zealand marine sponge, Mycale hentscheli, has shown potent antiproliferative activity in …