Roles of the microbiota of the female reproductive tract in gynecological and reproductive health

B Zhu, Z Tao, L Edupuganti, MG Serrano… - … and Molecular Biology …, 2022 - Am Soc Microbiol
The microbiome of the female reproductive tract defies the convention that high biodiversity
is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous …

Gut bacterial microbiome composition and statin intake—A systematic review

AM Dias, G Cordeiro, MM Estevinho… - Pharmacology …, 2020 - Wiley Online Library
Recently, the gut microbiome has become an important field of interest. Indeed, the
microbiome has been associated to numerous drug interactions and it is thought to influence …

Unveiling the role of Gardnerella vaginalis in polymicrobial Bacterial Vaginosis biofilms: the impact of other vaginal pathogens living as neighbors

J Castro, D Machado, N Cerca - The ISME journal, 2019 - academic.oup.com
Bacterial vaginosis (BV) is characterized by a highly structured polymicrobial biofilm, which
is strongly adhered to the vaginal epithelium and primarily consists of the bacterium …

Safety and efficacy of a novel vaginal anti-infective, TOL-463, in the treatment of bacterial vaginosis and vulvovaginal candidiasis: a randomized, single-blind, phase 2 …

JM Marrazzo, JC Dombrowski… - Clinical Infectious …, 2019 - academic.oup.com
Background Bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) present serious
reproductive health risks and management challenges, with poor control attributed to …

Advances in research on the relationship between vaginal microbiota and adverse pregnancy outcomes and gynecological diseases

F Zhao, X Hu, C Ying - Microorganisms, 2023 - mdpi.com
The human microbiota inhabiting different parts of the body has been shown to have a
significant impact on human health, with the gut microbiota being the most extensively …

The effect of the female genital tract and gut microbiome on reproductive dysfunction

W Cao, X Fu, J Zhou, Q Qi, F Ye, L Li, L Wang - BioScience Trends, 2023 - jstage.jst.go.jp
Microorganisms are ubiquitous in the human body; they are present in various areas
including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction …

Characterization of vaginal microbiota in women with recurrent spontaneous abortion that can be modified by drug treatment

F Zhao, Y Chen, J Gao, M Wu, C Li, Z Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Objective The role of vaginal microbiota in recurrent spontaneous abortion (RSA) remains
unknown. The purpose of this study was to investigate characteristics of vaginal microbiota …

Interaction of Gardnerella vaginalis and vaginolysin with the apical versus basolateral face of a three-dimensional model of vaginal epithelium

EM Garcia, V Kraskauskiene, JE Koblinski… - Infection and …, 2019 - Am Soc Microbiol
Studies have implicated Gardnerella vaginalis as an important etiological agent in bacterial
vaginosis (BV). It produces a cholesterol-dependent cytolysin, vaginolysin (VLY). In this …

Sequence Comparison of Vaginolysin from Different Gardnerella Species

EM Garcia, MG Serrano, L Edupuganti, DJ Edwards… - Pathogens, 2021 - mdpi.com
Gardnerella vaginalis has recently been split into 13 distinct species. In this study, we tested
the hypotheses that species-specific variations in the vaginolysin (VLY) amino acid …

Antimicrobial activity of bovine lactoferrin against Gardnerella species clinical isolates

A Pino, T Mazza, MAH Matthews, S Castellana… - Frontiers in …, 2022 - frontiersin.org
Gardnerella species play a key role in the development and recurrence of Bacterial
Vaginosis (BV), a common imbalance of the vaginal microbiota. Because of the high rates of …