Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy,
we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We …

Abstract 17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …

Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are
major regulators during mammary gland development, function and tumorigenesis …

Oestrogen receptor-α (ERα)-regulated transcription in breast cancer cells involves protein co-
factors that contribute to the regulation of chromatin structure. These include co-factors with …

A major question in transcription factor (TF) biology is why a TF binds to only a small fraction
of motif eligible binding sites in the genome. Using the estrogen receptor‐α as a model …

Estrogen receptor alpha (ERα, NR3A1) contributes through its expression in different tissues
to a spectrum of physiological processes, including reproductive system development and …

Estrogen receptors ERα and ERβ, members of the nuclear receptor superfamily, exert
profound effects on the gene expression and biological response programs of their target …

There has been a recent surge in the use of genome-wide methodologies to identify and
annotate the transcriptional regulatory elements in the human genome. Here we review …