Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response

JR Polimeni, LD Lewis - Progress in neurobiology, 2021 - Elsevier
Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …

Neuropsychological and neurophysiological mechanisms behind flickering light stimulus processing

ND Mankowska, M Grzywinska, PJ Winklewski… - Biology, 2022 - mdpi.com
Simple Summary Flickering light is used in research in many different fields. Despite
growing interest in the subject, there is still little known about its effects on the brain. The …

Next generation neural population models

S Coombes - Frontiers in Applied Mathematics and Statistics, 2023 - frontiersin.org
Low-dimensional neural mass models are often invoked to model the coarse-grained activity
of large populations of neurons and synapses and have been used to help understand the …

[HTML][HTML] Investigating mechanisms of fast BOLD responses: The effects of stimulus intensity and of spatial heterogeneity of hemodynamics

JE Chen, GH Glover, NE Fultz, BR Rosen, JR Polimeni… - NeuroImage, 2021 - Elsevier
Recent studies have demonstrated that fast fMRI can track neural activity well above the
temporal limit predicted by the canonical hemodynamic response model. While these …

[HTML][HTML] BOLD Response is more than just magnitude: Improving detection sensitivity through capturing hemodynamic profiles

G Chen, PA Taylor, RC Reynolds, E Leibenluft… - Neuroimage, 2023 - Elsevier
Typical fMRI analyses often assume a canonical hemodynamic response function (HRF) that
primarily focuses on the peak height of the overshoot, neglecting other morphological …

Contrasting measures of cerebrovascular reactivity between MRI and Doppler: a cross-sectional study of younger and older healthy individuals

CV Burley, ST Francis, KN Thomas… - Frontiers in …, 2021 - frontiersin.org
Cerebrovascular reactivity (CVR) is used as an outcome measure of brain health.
Traditionally, lower CVR is associated with ageing, poor fitness and brain-related conditions …

The thermodynamics of thinking: connections between neural activity, energy metabolism and blood flow

RB Buxton - … Transactions of the Royal Society B, 2021 - royalsocietypublishing.org
Several current functional neuroimaging methods are sensitive to cerebral metabolism and
cerebral blood flow (CBF) rather than the underlying neural activity itself. Empirically, the …

Gating by alpha band inhibition revised: a case for a secondary control mechanism

O Jensen - 2023 - osf.io
In recent decades there has been a growing interest in the role of neuronal oscillations in
the alpha band and how they support cognition. It is clear from intracranial animal …

Determining excitatory and inhibitory neuronal activity from multimodal fMRI data using a generative hemodynamic model

M Havlicek, D Ivanov, A Roebroeck… - Frontiers in …, 2017 - frontiersin.org
Hemodynamic responses, in general, and the blood oxygenation level-dependent (BOLD)
fMRI signal, in particular, provide an indirect measure of neuronal activity. There is strong …

[HTML][HTML] Physiological Modeling of the BOLD signal and Implications for Effective Connectivity: a primer

K Uludağ - Neuroimage, 2023 - Elsevier
In this primer, I provide an overview of the physiological processes that contribute to the
observed BOLD signal (ie, the generative biophysical model), including their time course …