Single-Cell RNA sequencing in Dissecting Microenvironment of Age-related Macular Degeneration: Challenges and Perspectives

Y Tan, J Huang, D Li, C Zou, D Liu, B Qin - Ageing Research Reviews, 2023 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness in individuals
over the age of 50 years, yet its etiology and pathogenesis largely remain uncovered. Single …

[HTML][HTML] High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration

AJ Kwok, J Lu, J Huang, BY Ip, VCT Mok… - Seminars in Cell & …, 2024 - Elsevier
High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly
enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well …

Time-inhomogeneous diffusion geometry and topology

G Huguet, A Tong, B Rieck, J Huang, M Kuchroo… - SIAM Journal on …, 2023 - SIAM
Diffusion condensation is a dynamic process that yields a sequence of multiscale data
representations that aim to encode meaningful abstractions. It has proven effective for …

Cuts: A fully unsupervised framework for medical image segmentation

C Liu, M Amodio, LL Shen, F Gao, A Avesta… - arXiv preprint arXiv …, 2022 - arxiv.org
In this work we introduce CUTS (Contrastive and Unsupervised Training for Segmentation),
a fully unsupervised deep learning framework for medical image segmentation to better …

Multiscale methods for signal selection in single-cell data

RS Hoekzema, L Marsh, O Sumray, TM Carroll, X Lu… - Entropy, 2022 - mdpi.com
Analysis of single-cell transcriptomics often relies on clustering cells and then performing
differential gene expression (DGE) to identify genes that vary between these clusters. These …

[PDF][PDF] Drug Repurposing for Age-Related Macular Degeneration (AMD) Based on Gene Co-Expression Network Analysis

S Samadi, Z Ghalandari, H MotieGhader… - … of Ophthalmic and …, 2019 - journals.sbmu.ac.ir
Background: Age-related macular degeneration (AMD) is a lesser-known eye disease in the
world that gradually destroys a person's vision by creating dark spots in the center of vision …