Mucoadhesive carriers for oral drug delivery

R Kumar, T Islam, M Nurunnabi - Journal of Controlled Release, 2022 - Elsevier
Among the various dosage forms, oral medicine has extensive benefits including ease of
administration and patients' compliance, over injectable, suppositories, ocular and nasal …

[HTML][HTML] Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

K Wu, SH Kwon, X Zhou, C Fuller, X Wang… - International Journal of …, 2024 - mdpi.com
The bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical
development, significantly impacting therapeutic efficacy and commercial viability. This …

Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment …

ME Elmoghayer, NM Saleh, II Abu Hashim - Drug Delivery and …, 2024 - Springer
Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus
both Type 1 and Type 2 Diabetes mellitus. However, its intrinsic poor solubility and …

Pharmaceutical applications of supercritical fluid extraction of emulsions for micro-/nanoparticle formation

H Park, JS Kim, S Kim, ES Ha, MS Kim, SJ Hwang - Pharmaceutics, 2021 - mdpi.com
Micro-/nanoparticle formulations containing drugs with or without various biocompatible
excipients are widely used in the pharmaceutical field to improve the physicochemical and …

High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation

EA Kim, JS Park, MS Kim, MY Jeong… - International Journal …, 2021 - Taylor & Francis
Background The titrated extract of Centella asiatica (CA) has received much attention as a
cosmeceutical ingredient owing to its anti-wrinkle effect. However, due to the low solubility …

Measurement and correlation of solubility of rivaroxaban in dichloromethane and primary alcohol binary solvent mixtures at different temperatures

JS Jeong, ES Ha, H Park, SK Lee, JS Kim… - Journal of Molecular …, 2022 - Elsevier
The solubility of rivaroxaban in different solvent mixtures consisting of dichloromethane and
primary alcohols, including methanol, ethanol, n-propanol, and n-butanol, was evaluated …

Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant

AS Lale, A Sirvi, S Debaje, S Patil… - European Journal of …, 2024 - Elsevier
This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …

Synthesis and Evaluation of BSA-Loaded PLGA–Chitosan Composite Nanoparticles for the Protein-Based Drug Delivery System

M Gaur, S Maurya, MS Akhtar, AB Yadav - ACS omega, 2023 - ACS Publications
The purpose of this study was to synthesize composite nanoparticles (NPs) based on poly
(d, l-lactic-co-glycolic acid)(PLGA) and chitosan (CS) and evaluate their suitability for the …

[HTML][HTML] Impact of route-dependent phase-II gut metabolism and enterohepatic circulation on the bioavailability and systemic disposition of resveratrol in rats and …

DG Han, SW Seo, E Choi, MS Kim, JW Yoo… - Biomedicine & …, 2022 - Elsevier
Resveratrol, a natural polyphenolic phytoalexin, is a dietary supplement that improves the
outcomes of metabolic, cardiovascular, and other age-related diseases due to its diverse …

Fast dissolving nanofiber mat for the local antimicrobial application of roxithromycin in oral cavity

S Kim, JJ Kim, JH Jeong, Y Kim, JH Park… - Materials Science and …, 2021 - Elsevier
Fast disintegrating and dissolving nanofiber (NF) mat was devised to deliver roxithromycin
for the treatment of the respiratory tract infection. NF membrane was made by an …