SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo
Glioblastoma (GBM) is a highly aggressive cancer with a dismal prognosis. Constitutively
active STAT3 has a causal role in GBM progression and is associated with poor patient …
active STAT3 has a causal role in GBM progression and is associated with poor patient …
The Role of CXCL11 and its Receptors in Cancer: Prospective but Challenging Clinical Targets
J Wang, X Ouyang, W Zhu, Q Yi, J Zhong - Cancer Control, 2024 - journals.sagepub.com
Chemokine ligand 11 is a member of the CXC chemokine family and exerts its biological
function mainly through binding to CXCR3 and CXCR7. The CXCL11 gene is ubiquitously …
function mainly through binding to CXCR3 and CXCR7. The CXCL11 gene is ubiquitously …
Upregulation of IFNɣ-mediated chemokines dominate the immune transcriptome of muscle-invasive urothelial carcinoma
Tumor inflammation is prognostically significant in high-grade muscle-invasive bladder
cancer (MIBC). However, the underlying mechanisms remain elusive. To identify …
cancer (MIBC). However, the underlying mechanisms remain elusive. To identify …
A multi-omics approach to understanding the tumour microenvironment in non-muscle invasive bladder cancer and its response to BCG immunotherapy
TF Wooldridge - openresearch.surrey.ac.uk
Bladder cancer (BC) is the 10th most common cancer world-wide with an estimated
570,000+ people being diagnosed in 2020. BC can be broadly subdivided into non-muscle …
570,000+ people being diagnosed in 2020. BC can be broadly subdivided into non-muscle …