Abstract Calcium (Ca 2+) and reactive oxygen species (ROS) are versatile signaling
molecules coordinating physiological and pathophysiological processes. While channels …

Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their
contribution to cancer pain has not been established. Here we report that depletion of sciatic …

Transient receptor potential (TRP) channels are a family of cation channels that depolarizes
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …

TRPM7 (transient receptor potential cation channel subfamily M member 7) regulates gene
expression and stress-induced cytotoxicity and is required in early embryogenesis through …

Coronary ischemia-reperfusion (IR) injury results from a blockage of blood supply to the
heart followed by restoration of perfusion, leading to oxidative stress induced pathological …

Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as
important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro …

Pain is a complex physiological process that includes many components. Growing evidence
supports the idea that oxidative stress and Ca2+ signaling pathways participate in pain …