Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

Invadosomes and caveolae are mechanosensitive structures that are implicated in
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …

Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from
the outer surface to the inner compartments of the cell. Long considered as a passive means …

Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …

Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …

Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to
efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by …