Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

The immunology of stroke: from mechanisms to translation

C Iadecola, J Anrather - Nature medicine, 2011 - nature.com
Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

Systemic inflammatory response index and futile recanalization in patients with ischemic stroke undergoing endovascular treatment

S Lattanzi, D Norata, AA Divani, M Di Napoli, S Broggi… - Brain Sciences, 2021 - mdpi.com
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of
acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct …

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Á Chamorro, U Dirnagl, X Urra, AM Planas - The Lancet Neurology, 2016 - thelancet.com
Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …

Embryonic stem cell derived small extracellular vesicles modulate regulatory T cells to protect against ischemic stroke

Y Xia, G Hu, Y Chen, J Yuan, J Zhang, S Wang, Q Li… - ACS …, 2021 - ACS Publications
Stem cell derived small extracellular vesicles (sEVs) have been proved to promote
neurological recovery after stroke. Recent studies demonstrate a phenomenal tissue repair …

Stroke and the immune system: from pathophysiology to new therapeutic strategies

R Macrez, C Ali, O Toutirais, B Le Mauff… - The Lancet …, 2011 - thelancet.com
Stroke is the second most common cause of death worldwide and a major cause of acquired
disability in adults. Despite tremendous progress in understanding the pathophysiology of …

DAMP signaling is a key pathway inducing immune modulation after brain injury

A Liesz, A Dalpke, E Mracsko, S Roth… - Journal of …, 2015 - Soc Neuroscience
Acute brain lesions induce profound alterations of the peripheral immune response
comprising the opposing phenomena of early immune activation and subsequent …

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

H Chen, Y He, S Chen, S Qi, J Shen - Pharmacological Research, 2020 - Elsevier
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Inflammatory responses in brain ischemia

M Kawabori, MA Yenari - Current medicinal chemistry, 2015 - ingentaconnect.com
Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …