ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)
M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …
maintenance of cellular processes and functions in the body. However, the excessive …
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the
lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory …
lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory …
TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization
J Tang, Y Kang, Y Zhou, N Shang, X Li… - The Journal of …, 2024 - Am Soc Clin Investig
Blood-brain barrier (BBB) disruption is a serious pathological consequence of traumatic
brain injury (TBI), for which there are limited therapeutic strategies. Tissue inhibitor of …
brain injury (TBI), for which there are limited therapeutic strategies. Tissue inhibitor of …
Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection
X Zhao, M Bie - BMC Cardiovascular Disorders, 2022 - Springer
Acute lung injury (ALI) and oxygenation impairment (OI) frequently occur in the patients with
acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in …
acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in …
BMP9 (bone morphogenetic protein-9)/Alk1 (activin-like kinase receptor type I) signaling prevents hyperglycemia-induced vascular permeability
N Akla, C Viallard, N Popovic, C Lora Gil… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Diabetic macular edema is a major cause of visual impairment. It is caused by
blood-retinal barrier breakdown that leads to vascular hyperpermeability. Current …
blood-retinal barrier breakdown that leads to vascular hyperpermeability. Current …
Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis
J Liu, Q Chen, S Liu, X Yang, Y Zhang, F Huang - Life sciences, 2018 - Elsevier
Aims Acute respiratory distress syndrome (ARDS), one of the serious form of acute lung
injury (ALI), is the primary cause of death in patients with ALI. Sini decoction (SND) is a …
injury (ALI), is the primary cause of death in patients with ALI. Sini decoction (SND) is a …
Inhibition of p38 MAPK mitigates lung ischemia reperfusion injury by reducing blood–air barrier hyperpermeability
T Wang, C Liu, L Pan, Z Liu, C Li, J Lin, Y He… - Frontiers in …, 2020 - frontiersin.org
Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological
process activated by lung transplantation and acute lung injury. The p38 mitogen-activated …
process activated by lung transplantation and acute lung injury. The p38 mitogen-activated …
Carnosol as a Nrf2 activator improves endothelial barrier function through antioxidative mechanisms
X Li, Q Zhang, N Hou, J Li, M Liu, S Peng… - International Journal of …, 2019 - mdpi.com
Oxidative stress is the main pathogenesis of diabetic microangiopathy, which can cause
microvascular endothelial cell damage and destroy vascular barrier. In this study, it is found …
microvascular endothelial cell damage and destroy vascular barrier. In this study, it is found …
Differential expression profile of plasma exosomal microRNAs in acute type A aortic dissection with acute lung injury
C Zhang, H Bai, L Zhang, Y Zhang, X Chen, R Shi… - Scientific Reports, 2022 - nature.com
MicroRNAs (miRNAs) packaged into exosomes mediate cell communication and contribute
to the pathogenesis of acute type A aortic dissection (ATAAD) with acute lung injury (ALI) …
to the pathogenesis of acute type A aortic dissection (ATAAD) with acute lung injury (ALI) …
Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation
Increased permeability of vascular lung tissues is a hallmark of acute lung injury and is often
caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin …
caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin …