A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …
use of outdated development and manufacturing technologies. The return on investment on …
Feasibility/Flexibility-based optimization for process design and operations
This paper provides an overview of concepts and computational approaches for the
evaluation of feasibility/flexibility and how they can be used for process design and process …
evaluation of feasibility/flexibility and how they can be used for process design and process …
QbD-steered development and validation of an RP-HPLC method for quantification of ferulic acid: Rational application of chemometric tools
The present work describes the systematic development of a simple, rapid, sensitive, robust,
effective and cost-effective reversed-phase high performance liquid chromatographic …
effective and cost-effective reversed-phase high performance liquid chromatographic …
Computational modeling and optimization of biofabrication in Tissue Engineering and Regenerative Medicine-a literature review
Biofabrication is the generation of biologically functional products from living cells and
biomaterials through bioprinting and subsequent maturation processes. Technological and …
biomaterials through bioprinting and subsequent maturation processes. Technological and …
A novel adaptive sampling based methodology for feasible region identification of compute intensive models using artificial neural network
Identification of feasible region of operations in multivariate processes is a problem of
interest in several fields. This is particularly challenging when the process model is black …
interest in several fields. This is particularly challenging when the process model is black …
Design space determination of pharmaceutical processes: Effects of control strategies and uncertainty
The identification of process Design Space (DS) is of high interest in highly regulated
industrial sectors, such as pharmaceutical industry, where assurance of manufacturability …
industrial sectors, such as pharmaceutical industry, where assurance of manufacturability …
Novel flexibility index formulations for the selection of the operating range within a design space
MP Ochoa, S García-Muñoz, S Stamatis… - Computers & Chemical …, 2021 - Elsevier
The importance of the Design Space (DS) definition lies in the assurance of quality, a key
goal of Quality by Design, and in the broadening from a single acceptable operating point, to …
goal of Quality by Design, and in the broadening from a single acceptable operating point, to …
PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets
D Casas-Orozco, D Laky, V Wang, M Abdi… - Computers & chemical …, 2021 - Elsevier
Process design and optimization continue to provide computational challenges as the
chemical engineering and process optimization communities seek to address more complex …
chemical engineering and process optimization communities seek to address more complex …
A novel framework for the identification of complex feasible space
Feasibility analysis is suitable to determine the combinations of input parameters that satisfy
all operating and quality constraints, ie, the process design space. In the presence of disjoint …
all operating and quality constraints, ie, the process design space. In the presence of disjoint …
A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes
A five-step method is proposed for determining the design space of mesenchymal stem cell
(MSC) cultivation processes incorporating system dynamics and variabilities. The method …
(MSC) cultivation processes incorporating system dynamics and variabilities. The method …