Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to
pharmacological tolerance and receptor desensitization in the nervous system. We found …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1)
inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …