Abstract Pharmacogenomic Polygenic Risk Scores (PRS) have emerged as a tool to
address the polygenic nature of pharmacogenetic phenotypes, increasing the potential to …

Spondyloarthropathies (SpA), including ankylosing spondylitis (AS) and psoriatic arthritis
(PsA), have been shown to have a substantial genetic predisposition based on heritability …

Polygenic scores in real-world cardiovascular risk prediction: the path forward for assessing
worth? Page 1 Polygenic scores in real-world cardiovascular risk prediction: the path forward …

Background: Cardiovascular disease is a leading cause of mortality globally and a major
contributor to disability. Traditional risk factors, as initially established in the FRAMINGHAM …

Precision medicine (PM), also termed stratified, individualised, targeted, or personalised
medicine, embraces a rapidly expanding area of research, knowledge, and practice. It …

Background and Aims A cardiovascular disease polygenic risk score (CVD-PRS) can stratify
individuals into different categories of cardiovascular risk, but whether the addition of a CVD …

The course of COVID-19 is highly variable, with genetics playing a significant role. Through
large-scale genetic association studies, a link between single nucleotide polymorphisms …

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the
world. However, advances in genetics, omics research, machine learning (ML), and …

Background: Polygenic risk scores (PRS) have demonstrated predictive validity across a
range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As …

Atherosclerotic cardiovascular disease (ASCVD), including coronary artery disease (CAD),
is the most common cause of death worldwide. One of the most important risk factors is …