Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Predictive processing postulates the existence of prediction error neurons in cortex. Neurons
with both negative and positive prediction error response properties have been identified in …

The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …

Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

Single-cell or single-nucleus transcriptomics is a powerful tool for identifying cell types and
cell states. However, hypotheses derived from these assays, including gene expression …

Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …

Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes …