Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …

Current 3D printing of tissue is restricted by the use of biomaterials that do not recapitulate
the native properties of the extracellular matrix (ECM). These restrictions have thus far …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) 2A receptor agonists have recently emerged
as promising new treatment options for a variety of disorders. The recent success of these …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Background & Aims Desmoplasia and poor vascularity cause severe metabolic stress in
pancreatic ductal adenocarcinomas (PDACs). Serotonin (5-HT) is a neuromodulator with …