The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

CORUM is a database that provides a manually curated repository of experimentally
characterized protein complexes from mammalian organisms, mainly human (67%), mouse …

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional
dysregulation that results in a block in differentiation and increased malignant self-renewal …

Mitochondrial Ca2+ ions are crucial regulators of bioenergetics and cell death pathways.
Mitochondrial Ca2+ content and cytosolic Ca2+ homeostasis strictly depend on Ca2+ …

NUP98 fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98
fusion proteins share an intrinsically disordered region (IDR) in the NUP98 N terminus …

Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

Acute myeloid leukemia (AML) remains difficult to treat and requires new therapeutic
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …