Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …

In recent years, the Zika virus has emerged from a neglected flavivirus to a health-
threatening pathogen that causes epidemic outbreaks associated with neurological …

Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

Zika virus (ZIKV) is a human pathogenic arbovirus. So far, neither a specific treatment nor a
vaccination against ZIKV infections has been approved. Starting from our previously …

Zika virus belongs to the Flavivirus family of RNA viruses, which include other important
human pathogens such as dengue and West Nile virus. There are no approved antiviral …

Zika virus (ZIKV) infections are associated with severe neurological complications and are a
global public health concern. There are no approved vaccines or antiviral drugs to inhibit …

Zika Virus (ZIKV) is a positive-strand RNA virus that can lead to Guillain-Barré syndrome or
encephalitis in some individuals and hence presents a serious public health risk. Since the …

With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses
a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved …

The NS2B-NS3 protease (NS2B-NS3pro) is regarded as an interesting molecular target for
drug design, discovery, and development because of its essential role in the Zika virus …

According to WHO, dengue virus is classed among major threats for future pandemics and
remains at large an unmet medical need as there are currently no relevant antiviral drugs …