Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …
craving are often provoked by acute exposure to the self-administered drug or related drugs …
Opiate versus psychostimulant addiction: the differences do matter
The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
Stress is a complex experience that carries both aversive and motivating properties. Chronic
stress causes an increase in the risk of depression, is well known to increase relapse of drug …
stress causes an increase in the risk of depression, is well known to increase relapse of drug …
Pain, nicotine, and smoking: research findings and mechanistic considerations.
Tobacco addiction and chronic pain represent 2 highly prevalent and comorbid conditions
that engender substantial burdens upon individuals and systems. Interrelations between …
that engender substantial burdens upon individuals and systems. Interrelations between …
Corticotropin releasing factor: a key role in the neurobiology of addiction
Drug addiction is a chronically relapsing disorder characterized by loss of control over intake
and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie …
and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie …
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
Several neuropsychological hypotheses have been formulated to explain the transition to
addiction, including hedonic allostasis, incentive salience, and the development of habits. A …
addiction, including hedonic allostasis, incentive salience, and the development of habits. A …
Effects of stress on alcohol drinking: a review of animal studies
HC Becker, MF Lopez, TL Doremus-Fitzwater - Psychopharmacology, 2011 - Springer
Rationale While stress is often proposed to play a significant role in influencing alcohol
consumption, the relationship between stress and alcohol is complex and poorly …
consumption, the relationship between stress and alcohol is complex and poorly …
Stress, habits, and drug addiction: a psychoneuroendocrinological perspective.
It is well known that stress is a significant risk factor for the development of drug addiction
and addiction relapse. Remarkably, the cognitive processes involved in the effects of stress …
and addiction relapse. Remarkably, the cognitive processes involved in the effects of stress …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …