Genetic isolates, as shown empirically by the Finnish, Old Order Amish, Hutterites, Sardinian
and Jewish communities among others, represent a most important and powerful tool in …

An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

The development of epitope-based vaccines, which have wide population coverage, is
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …

The epidemiology of multiple sclerosis (MS) has been thoroughly studied in developed
countries, particularly in areas traditionally known for their high prevalence. However, there …

OBJECTIVE: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis
(MS) in a Colombian population and to estimate the common effect size of HLA class II on …

Background The prevalence of multiple sclerosis (MS) in Latin America is generally
considered low to moderate. However, accurate data regarding MS epidemiology in …

Genetic isolates have been successfully used in the study of complex traits, mainly because
due to their features, they allow a reduction in the complexity of the genetic models …

Clear evidence has been presented correlating gene polymorphisms at 6p21. 3-21.4
(containing HLA and TNF) and the predisposition to acquire multiple sclerosis (MS). In a …

La esclerosis múltiple (EM) es una enfermedad neurológica de desvastadoras
consecuencias. Aunque se ha considerado, usualmente, como una enfermedad …

La Esclerosis Múltiple (EM) es una enfermedad crónica desmielinizante del Sistema
Nervioso Central, de causa desconocida, de pronóstico variable con tratamiento de alto …