Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

The immune system recognizes and is poised to eliminate cancer but is held in check by
inhibitory receptors and ligands. These immune checkpoint pathways, which normally …

NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-
testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit …

Background Advanced prostate cancer remains one of the most common and deadly
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …

Purpose Combining immunotherapeutic agents with different mechanisms of action may
enhance efficacy. We describe the safety and efficacy of talimogene laherparepvec (T-VEC; …

Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging
the immune system to seek and destroy cancer cells. At this time, the United States Food …

Chimeric antigen receptor (CAR) T cell therapy has been successful in clinical trials against
hematological cancers, but has experienced challenges in the treatment of solid tumors …

Hypophysitis is a chronic inflammation of the pituitary gland of unknown (primary forms) or
recognizable (secondary forms) etiology, such as the use of ipilimumab in cancer …

Background: Therapeutic monoclonal anti-cytotoxic T-lymphocyte-associated antigen 4
(CTLA-4) antibodies are associated with immune-mediated enterocolitis. The aim of this …