Futility Interim Analysis Based on Probability of Success Using a Surrogate Endpoint
R Fougeray, L Vidot, M Ratta, Z Teng… - Pharmaceutical …, 2024 - Wiley Online Library
In clinical trials with time‐to‐event data, the evaluation of treatment efficacy can be a long
and complex process, especially when considering long‐term primary endpoints. Using …
and complex process, especially when considering long‐term primary endpoints. Using …
Group sequential testing of a treatment effect using a surrogate marker
L Parast, J Bartroff - Biometrics, 2024 - academic.oup.com
The identification of surrogate markers is motivated by their potential to make decisions
sooner about a treatment effect. However, few methods have been developed to actually …
sooner about a treatment effect. However, few methods have been developed to actually …
On the Concepts, Methods, and Use of “Probability of Success” for Drug Development Decision‐Making: A Scoping Review
A Cetinyurek Yavuz, MBN Fayyad, C Jiang… - Clinical Pharmacology … - Wiley Online Library
Drug development is a lengthy process with considerable uncertainty at each milestone.
Several trials are needed to progress to confirmatory evaluation and establish a positive …
Several trials are needed to progress to confirmatory evaluation and establish a positive …