Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets

YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

Nutritional management of chronic kidney disease

K Kalantar-Zadeh, D Fouque - New England Journal of Medicine, 2017 - Mass Medical Soc
Nutritional Management of Chronic Kidney Disease | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

[HTML][HTML] The systemic nature of CKD

C Zoccali, R Vanholder, ZA Massy, A Ortiz… - Nature Reviews …, 2017 - nature.com
The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Biochemical and clinical impact of organic uremic retention solutes: a comprehensive update

R Vanholder, A Pletinck, E Schepers, G Glorieux - Toxins, 2018 - mdpi.com
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

p-Cresyl Sulfate

T Gryp, R Vanholder, M Vaneechoutte, G Glorieux - Toxins, 2017 - mdpi.com
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several
uremic solutes are retained. Some of these exert toxic effects, which are called uremic …

Inflammation and premature ageing in chronic kidney disease

T Ebert, SC Pawelzik, A Witasp, S Arefin, S Hobson… - Toxins, 2020 - mdpi.com
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial

M Rossi, DW Johnson, M Morrison… - Clinical Journal of the …, 2016 - journals.lww.com
Results Of 37 individuals randomized (age= 69±10 years old; 57% men; eGFR= 24±8
ml/min per 1.73 m 2), 31 completed the study. Synbiotic therapy did not significantly reduce …

Chronic kidney disease and the gut microbiome

GP Hobby, O Karaduta, GF Dusio… - American Journal …, 2019 - journals.physiology.org
The gut microbiome is composed of a diverse population of bacteria that have beneficial and
adverse effects on human health. The microbiome has recently gained attention and is …

Role of the gut microbiome in uremia: a potential therapeutic target

A Ramezani, ZA Massy, B Meijers, P Evenepoel… - American Journal of …, 2016 - Elsevier
Also known as the “second human genome,” the gut microbiome plays important roles in
both the maintenance of health and the pathogenesis of disease. The symbiotic relationship …