Molecular pathogenesis of pulmonary fibrosis, with focus on pathways related to TGF-β and the ubiquitin-proteasome pathway

N Inui, S Sakai, M Kitagawa - International journal of molecular sciences, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During
the past decade, novel pathogenic mechanisms of IPF have been elucidated that have …

Fibrotic idiopathic interstitial lung disease: The molecular and cellular key players

AV Samarelli, R Tonelli, A Marchioni, G Bruzzi… - International Journal of …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) that are known as diffuse parenchymal lung diseases
(DPLDs) lead to the damage of alveolar epithelium and lung parenchyma, culminating in …

Identification and validation of aging-related genes in idiopathic pulmonary fibrosis

J He, X Li - Frontiers in genetics, 2022 - frontiersin.org
Aging plays a significant role in the occurrence and development of idiopathic pulmonary
fibrosis (IPF). In this study, we aimed to identify and verify potential aging-associated genes …

Natural product-based potential therapeutic interventions of pulmonary fibrosis

M Hasan, NC Paul, SK Paul, ASM Saikat, H Akter… - Molecules, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of
mortality. The potential factors causing PF include viral infections, radiation exposure, and …

Nintedanib inhibits endothelial mesenchymal transition in bleomycin-induced pulmonary fibrosis via focal adhesion kinase activity reduction

WK Yu, WC Chen, VYF Su, HC Shen, HH Wu… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD). Pulmonary
fibroblasts play an important role in the development of IPF. Emerging evidence indicates …

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

P Pi, Z Zeng, L Zeng, B Han, X Bai, S Xu - Frontiers in Pharmacology, 2023 - frontiersin.org
As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought …

[HTML][HTML] Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs …

DH El-Kashef, ME Youssef, M Nasr, M Alrouji… - Biomedicine & …, 2022 - Elsevier
Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis
are still unobvious. Effective treatments are urgently needed considering that lung …

STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations

OA Mohammed, MA Abdel-Reheim, MMS Alamri… - Pharmaceuticals, 2023 - mdpi.com
Liver fibrosis is a progressive condition characterized by the build-up of fibrous tissue
resulting from long-term liver injury. Although there have been advancements in research …

HSP90 as a regulator of extracellular matrix dynamics

A Chakraborty, AL Edkins - Biochemical Society Transactions, 2021 - portlandpress.com
The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled
from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular …

Potential of resveratrol in the treatment of interstitial lung disease

R Huo, X Huang, Y Yang, Y Yang, J Lin - Frontiers in Pharmacology, 2023 - frontiersin.org
Interstitial lung disease (ILD) is a heterogeneous group of diseases characterized by lung
injury caused by lung fibroblast proliferation, interstitial inflammation, and fibrosis. Different …