[HTML][HTML] Regulation of innate immunity by Nrf2
D van der Horst, ME Carter-Timofte… - Current Opinion in …, 2022 - Elsevier
The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …
investigated as a regulator of redox homeostasis. However, research over the past years …
Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: emerging role in immune cells and immunosuppressive signaling
J Jin, Q Zhao, Z Wei, K Chen, Y Su, X Hu, X Peng - Cell & Bioscience, 2023 - Springer
Cell proliferation and function require nutrients, energy, and biosynthesis activity to duplicate
repertoires for each daughter. It is therefore not surprising that tumor microenvironment …
repertoires for each daughter. It is therefore not surprising that tumor microenvironment …
MAVS integrates glucose metabolism and RIG-I-like receptor signaling
Q He, Y Huang, L Nie, S Ren, G Xu, F Deng… - Nature …, 2023 - nature.com
MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria,
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …
Virus-like particle–mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection
Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …
A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment
J Chen, R Chen, J Huang - Frontiers in Immunology, 2024 - frontiersin.org
Background Cancer-associated fibroblasts (CAFs) are the primary stromal cells found in
tumor microenvironment, and display high plasticity and heterogeneity. By using single-cell …
tumor microenvironment, and display high plasticity and heterogeneity. By using single-cell …
Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology
Previous studies from our laboratory and others have established the dendritic cell (DC) as a
key target of RSV that drives infection-induced pathology. Analysis of RSV-induced …
key target of RSV that drives infection-induced pathology. Analysis of RSV-induced …