Microglia in aging and Alzheimer's disease: a comparative species review

MK Edler, I Mhatre-Winters, JR Richardson - Cells, 2021 - mdpi.com
Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

The beneficial role of natural endocrine disruptors: Phytoestrogens in Alzheimer's disease

A Domańska, A Orzechowski… - Oxidative Medicine …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia with a growing incidence
rate primarily among the elderly. It is a neurodegenerative, progressive disorder leading to …

[HTML][HTML] Alzheimer's disease neuropathological change in aged non-primate mammals

I Ferrer - International Journal of Molecular Sciences, 2024 - mdpi.com
Human brain aging is characterized by the production and deposition of β-amyloid (Aβ) in
the form of senile plaques and cerebral amyloid angiopathy and the intracellular …

Bridging the gap between Alzheimer's disease and Alzheimer's-like diseases in animals

A Gołaszewska, W Bik, T Motyl… - International journal of …, 2019 - mdpi.com
The average life span steadily grows in humans and in animals kept as pets or left in
sanctuaries making the issue of elderly-associated cognitive impairment a hot-spot for …

Aged cattle brain displays Alzheimer's disease-like pathology and promotes brain amyloidosis in a transgenic animal model

I Moreno-Gonzalez, G Edwards III, R Morales… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the
cause of AD neurodegenerative changes is not fully understood, extensive evidence …

Amyloid precursor protein, lipofuscin accumulation and expression of autophagy markers in aged bovine brain

D De Biase, A Costagliola, TB Pagano, G Piegari… - BMC veterinary …, 2017 - Springer
Background Autophagy is a highly regulated process involving the bulk degradation of
cytoplasmic macromolecules and organelles in mammalian cells via the lysosomal system …

Amyloid-β and phosphorylated tau screening in bottlenose dolphin (Tursiops truncatus) and striped dolphin (Stenella coeruleoalba) brains from Italy reveals distinct …

K Orekhova, C Testori, F Giorda, C Grattarola… - PloS one, 2024 - journals.plos.org
Cetacean brains are uniquely adapted to diving, but can be affected by diseases and
exposure to toxins, triggering neurodegenerative processes that may cause stranding. Some …

Fluorescent probes for neuroscience: imaging ex vivo brain tissue sections

B Schwehr, D Hartnell, G Ellison, M Hindes, B Milford… - Analyst, 2024 - pubs.rsc.org
Neurobiological research relies heavily on imaging techniques, such as fluorescence
microscopy, to understand neurological function and disease processes. However, the …

[HTML][HTML] Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates

G Lepore, S Succu, MG Cappai, A Frau, A Senes… - Animals, 2024 - mdpi.com
Simple Summary Brain aging in mammals is characterized by morphological and functional
changes in neural cells. This process, although physiological, leads to progressive cerebral …

Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys

AJ Malbon, L Sordo, LA Wilson, D Gunn-Moore… - Neurobiology of …, 2022 - Elsevier
Neurodegenerative disorders are gaining ever more importance in ageing populations of
animals and people. Altered insulin signaling and type II diabetes have been linked to the …