The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Lactylation was initially discovered on human histones. Given its nascence, its occurrence
on nonhistone proteins and downstream functional consequences remain elusive. Here we …

Lysine L-lactylation [K (L-la)] is a newly discovered histone mark stimulated under conditions
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

Lactate has diverse roles in the brain at the molecular and behavioral levels under
physiological and pathophysiological conditions. This study investigates whether lysine …

Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Lactylation is a lactate-induced post-translational modification best known for its roles in
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …