Importance Bacterial meningitis is a worldwide health problem, with incidence rates ranging
from approximately 0.9 per 100 000 individuals per year in high-income countries to 80 per …

Summary Background The FilmArray Meningitis/Encephalitis (FA/ME) panel brings benefits
in clinical practice, but its diagnostic test accuracy (DTA) remains unclear. We aimed to …

Abstract The Infectious Diseases Society of America (IDSA) Standards and Practice
Guidelines Committee collaborated with partner organizations to convene a panel of 10 …

Bacterial meningitis is a severe infectious disease of the membranes lining the brain
resulting in a high mortality and morbidity throughout the world. In the past decades the …

Rapid diagnosis and treatment of infectious meningitis and encephalitis are critical to
minimize morbidity and mortality. Comprehensive testing of cerebrospinal fluid (CSF) often …

The epidemiology of bacterial meningitis has changed as a result of the widespread use of
conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the …

Rapid diagnosis and treatment of acute community-acquired bacterial meningitis reduces
mortality and neurological sequelae, but can be delayed by atypical presentation …

OBJECTIVES: Cerebrospinal fluid (CSF) lactate is produced by bacterial anaerobic
metabolism and is not affected by blood lactate concentration, an advantage over CSF …

Despite remarkable progress in prevention and treatment, infectious diseases affecting the
central nervous system remain an important source of morbidity and mortality, particularly in …

Background Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard
for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously …