Pharmacomodulation of membrane channels is an essential topic in the study of
physiological conditions and disease status. Transient receptor potential (TRP) channels are …

Already for centuries, humankind is driven to understand the physiological and pathological
mechanisms that occur in our brains. Today, we know that ion channels play an essential …

Brain disorders include neurodegenerative diseases (NDs) with different conditions that
primarily affect the neurons and glia in the brain. However, the risk factors and …

Obesity prevalence became a severe global health problem and it is caused by an
imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major …

Alzheimer's disease (AD) is a devastating disorder with a multifaceted aetiology
characterized by dementia, which later progresses to cognitive impairment. Significant …

Parkinson's disease (PD) is a common neurodegenerative disorder, which involves
degeneration of dopaminergic neurons that are present in the substantia nigra pars …

Background: Ca2 influx plays an essential role in the physiological and pathophysiologic
processes of several nervous system diseases. The transient receptor-potential channels …

Recently, Ganoderma lucidum spores (GLS) have shown anti-epileptic effects. However,
there are no reports on the anti-epileptic effects of its chemical constituents ganoderic acids …

Endothelin-1 (ET-1) and bradykinin (BK) are endogenous peptides that signal through
Gαq/11-protein coupled receptors (GPCRs) to produce nociceptor sensitization and pain …

Exposure to air pollution and particulate matter (PM) is linked to adverse health effects,
including neurodegenerative diseases. While underlying mechanisms are still unknown …