Colorectal cancers among patients with a familial risk of this disorder account for
approximately one of five cases of this disease. Many cases can be prevented by the …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer
(CRC) have no detectable germline mutations in the known cancer predisposition genes …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic
stability. In a broad sense, all main functions of the MMR system, including the correction of …

Endometrial cancer is the most common cancer in women with Lynch syndrome. The
identification of individuals with Lynch syndrome is desirable because they can benefit from …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

Background The identification of mutations in germ-line DNA mismatch-repair genes at the
time of diagnosis of colorectal cancer is important in the management of the disease …

Abstract In 1994, the International Collaborative Group on Hereditary Nonpolyposis
Colorectal Cancer (ICG-HNPCC) established an international database of mutations …