The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Drug resistance constitutes a major challenge in designing melanoma therapies.
Microenvironment-driven tumor heterogeneity and plasticity play a key role in this …

Melanoma, a highly heterogeneous tumor, is comprised of a functionally diverse spectrum of
cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment …

Background Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide.
Chemotherapy resistance represents a significant clinical challenge and is the main reason …

It is increasingly appreciated that cancer cell heterogeneity and plasticity constitute major
barriers to effective clinical treatments and long-term therapeutic efficacy. Research in the …

Despite the general focus on an invasive and de-differentiated phenotype as main driver of
cancer metastasis, in melanoma patients many metastatic lesions display a high degree of …

Metastatic melanoma is an aggressive disease, despite recent improvements in therapy.
Eradicating all melanoma cells even in drug-sensitive tumors is unsuccessful in patients …

Therapies that target oncogenes and immune checkpoint molecules constitute a major
group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects …

Rationale: Recurrent and metastatic cancers often undergo a period of dormancy, which is
closely associated with cellular quiescence, a state whereby cells exit the cell cycle and are …

Functional genomics is an emerging field focused on elucidating the functions of genes or
proteins, which can help solve challenges related to reliable cancer therapy. One of the …