Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development

TA McKinsey, R Foo, CG Anene-Nzelu… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy

M Zhou, M Yuan, M Zhang, C Lei, O Aras… - European journal of …, 2021 - Elsevier
Histone deacetylases (HDACs) play an important role in regulating the expression of genes
involved in tumorigenesis and tumor maintenance, and hence they have been considered …

Salt-induced hepatic inflammatory memory contributes to cardiovascular damage through epigenetic modulation of SIRT3

P Gao, M You, L Li, Q Zhang, X Fang, X Wei, Q Zhou… - Circulation, 2022 - Am Heart Assoc
Background: High salt intake is the leading dietary risk factor for cardiovascular diseases.
Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty …

Mitochondrial epigenetics in aging and cardiovascular diseases

A Mongelli, A Mengozzi, M Geiger, E Gorica… - Frontiers in …, 2023 - frontiersin.org
Mitochondria are cellular organelles which generate adenosine triphosphate (ATP)
molecules for the maintenance of cellular energy through the oxidative phosphorylation …

[HTML][HTML] An update on the mechanisms of Takotsubo syndrome:“At the end an acute coronary syndrome”

F Crea, G Iannaccone, G La Vecchia… - Journal of Molecular and …, 2024 - Elsevier
Takotsubo syndrome (TTS) is an acute reversible form of myocardial dysfunction, often
preceded by a physical or emotional stressful event, that acts as a trigger. Despite, recent …

Genetic and epigenetic factors of Takotsubo syndrome: a systematic review

V Ferradini, D Vacca, B Belmonte, R Mango… - International Journal of …, 2021 - mdpi.com
Takotsubo syndrome (TTS), recognized as stress's cardiomyopathy, or as left ventricular
apical balloon syndrome in recent years, is a rare pathology, described for the first time by …

[HTML][HTML] “Obesity paradox” and takotsubo syndrome

JE Madias - … Journal of Cardiology Cardiovascular Risk and …, 2022 - Elsevier
Background An “obesity paradox” has been reported in patients with hypertension and heart
failure, in which obese patients fare better than patients with normal-weight. The purpose of …

Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor

K Al-Hasani, I Khurana, L Mariana… - … and Targeted Therapy, 2022 - nature.com
Abstract Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-
producing β-cells in the pancreas. An unmet need in diabetes management, current therapy …

Epigenetic remodeling in heart failure with preserved ejection fraction

S Ambrosini, E Gorica, SA Mohammed… - Current Opinion in …, 2022 - journals.lww.com
Acquired epigenetic signatures during the lifetime can contribute to derail molecular
pathways involved in HFpEF. A scrutiny investigation of the individual epigenetic landscape …

Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms

SG Royce, PV Licciardi, RC Beh, JE Bourke… - Cellular and Molecular …, 2022 - Springer
Sulforaphane has been investigated in human pathologies and preclinical models of airway
diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the …