The war against tuberculosis: A review of natural compounds and their derivatives
M Maiolini, S Gause, J Taylor, T Steakin, G Shipp… - Molecules, 2020 - mdpi.com
Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a
major threat to public health, especially in middle and low-income countries. Worldwide in …
major threat to public health, especially in middle and low-income countries. Worldwide in …
Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens
JL Hicks, KEA Oldham, J McGarvie… - Bioscience …, 2022 - portlandpress.com
Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …
resistance is one the biggest threats to global health and food security. Identifying new and …
Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase
Mycobacterium tuberculosis is the etiological agent of tuberculosis in humans and is
responsible for more than two million deaths annually. M. tuberculosis isocitrate lyase …
responsible for more than two million deaths annually. M. tuberculosis isocitrate lyase …
Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
Current insights into the chemistry and antitubercular potential of benzimidazole and imidazole derivatives
D Parwani, S Bhattacharya, A Rathore… - Mini Reviews in …, 2021 - ingentaconnect.com
Tuberculosis is a disease caused by Mycobacterium tuberculosis (Mtb), affecting millions of
people worldwide. The emergence of drug resistance is a major problem in the successful …
people worldwide. The emergence of drug resistance is a major problem in the successful …
Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity
Tuberculosis remains a major health problem accentuated by the rise of resistance to all
available drugs. Therefore, this study was launched to discover a novel antituberculosis …
available drugs. Therefore, this study was launched to discover a novel antituberculosis …
Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase
Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a key enzyme of the glyoxylate cycle
that catalyzes the cleavage of isocitrate to succinate and glyoxylate and is a potential …
that catalyzes the cleavage of isocitrate to succinate and glyoxylate and is a potential …
Structural and energetic understanding of novel natural inhibitors of Mycobacterium tuberculosis malate synthase
Persistent infection by Mycobacterium tuberculosis requires the glyoxylate shunt. This is a
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
Development of efflux pump inhibitors in antituberculosis therapy
L Song, X Wu - International journal of antimicrobial agents, 2016 - Elsevier
Resistance and tolerance to antituberculosis (anti-TB) drugs, especially the first-line drugs,
has become a serious problem in anti-TB therapy. Efflux of antimicrobial agents via bacterial …
has become a serious problem in anti-TB therapy. Efflux of antimicrobial agents via bacterial …
Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site
Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a crucial enzyme of the glyoxylate
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …