Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

LM Ramer, MS Ramer, EJ Bradbury - The Lancet Neurology, 2014 - thelancet.com
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

JW Rowland, GWJ Hawryluk, B Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …

Therapeutic interventions after spinal cord injury

S Thuret, LDF Moon, FH Gage - Nature Reviews Neuroscience, 2006 - nature.com
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Restoration of sensorimotor functions after spinal cord injury

V Dietz, K Fouad - Brain, 2014 - academic.oup.com
The purpose of this review is to discuss the achievements and perspectives regarding
rehabilitation of sensorimotor functions after spinal cord injury. In the first part we discuss …

Concise review: a comprehensive analysis of reported adverse events in patients receiving unproven stem cell-based interventions

G Bauer, M Elsallab… - Stem cells translational …, 2018 - academic.oup.com
The promise of stem cell (SC) therapies to restore functions of damaged tissues and organs
brings enormous hope to patients, their families, loved ones, and caregivers. However, limits …

Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial

A Mackay-Sim, F Feron, J Cochrane… - Brain, 2008 - academic.oup.com
Olfactory ensheathing cells show promise in preclinical animal models as a cell
transplantation therapy for repair of the injured spinal cord. This is a report of a clinical trial of …

Stem cell technology for neurodegenerative diseases

JS Lunn, SA Sakowski, J Hur… - Annals of neurology, 2011 - Wiley Online Library
Over the past 20 years, stem cell technologies have become an increasingly attractive
option to investigate and treat neurodegenerative diseases. In the current review, we …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …