Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults

JS Zifodya, I Schiller, N Dendukuri… - Cochrane Database …, 2019 - cochranelibrary.com
Background Xpert MTB/RIF (Xpert MTB/RIF) and Xpert MTB/RIF Ultra (Xpert Ultra), the
newest version, are the only World Health Organization (WHO)‐recommended rapid tests …

Mycobacteriophages: from petri dish to patient

GF Hatfull - PLoS Pathogens, 2022 - journals.plos.org
Mycobacteriophages—bacteriophages infecting Mycobacterium hosts—contribute
substantially to our understanding of viral diversity and evolution, provide resources for …

Actinobacteriophages: genomics, dynamics, and applications

GF Hatfull - Annual review of virology, 2020 - annualreviews.org
Actinobacteriophages are viruses that infect bacterial hosts in the phylum Actinobacteria.
More than 17,000 actinobacteriophages have been described and over 3,000 complete …

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates …

KA Cohen, T Abeel, A Manson McGuire… - PLoS …, 2015 - journals.plos.org
Background The continued advance of antibiotic resistance threatens the treatment and
control of many infectious diseases. This is exemplified by the largest global outbreak of …

Bacteriophage-based advanced bacterial detection: Concept, mechanisms, and applications

W Hussain, MW Ullah, U Farooq, A Aziz… - Biosensors and …, 2021 - Elsevier
Some bacterial species are deadly disease-causing pathogens with high morbidity and
mortality in humans worldwide. Key interfaces in the transmission of bacterial pathogens …

Phage-based applications in synthetic biology

S Lemire, KM Yehl, TK Lu - Annual review of virology, 2018 - annualreviews.org
Bacteriophage research has been instrumental to advancing many fields of biology, such as
genetics, molecular biology, and synthetic biology. Many phage-derived technologies have …

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

JS Zifodya, JS Kreniske, I Schiller… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health
Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and …

Mechanisms and detection methods of Mycobacterium tuberculosis rifampicin resistance: The phenomenon of drug resistance is complex

G Xu, H Liu, X Jia, X Wang, P Xu - Tuberculosis, 2021 - Elsevier
Tuberculosis (TB) is an infectious disease that poses a serious threat to human health.
Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key …

Mycobacteriophages

GF Hatfull - Microbiology spectrum, 2018 - Am Soc Microbiol
Mycobacteriophages are viruses that infect mycobacterial hosts. A large number of
mycobacteriophages have been isolated and genomically characterized, providing insights …

Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

P Jain, BC Weinrick, EJ Kalivoda, H Yang, V Munsamy… - MBio, 2016 - Am Soc Microbiol
Persisters are the minor subpopulation of bacterial cells that lack alleles conferring
resistance to a specific bactericidal antibiotic but can survive otherwise lethal concentrations …