Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …

Metformin is a first-line medication for type II diabetes. Numerous studies have shown that
metformin not only has hypoglycemic effects, but also modulates many physiological and …

Periodontal ligament stem cell (PDLSC)-based tissue engineering is an important method
for regenerating lost bone in periodontitis. Maintaining or enhancing the osteogenic …

This paper provides a detailed assessment of hormetic dose responses by human
periodontal ligament stem cells (hPDLSCs). Hormetic dose responses were induced by a …

Senotherapeutics are new drugs that can modulate senescence phenomena within tissues
and reduce the onset of age-related pathologies. Senotherapeutics are divided into …

Melatonin possesses multi-organ and pleiotropic effects with potency to control
angiogenesis at both molecular and cellular levels. To date, many efforts have been made to …

Purpose: The effect of mesenchymal stem cells (MSCs) on the immortality features of
malignant cells, such as hematologic cancerous cells, are controversial, and the associated …

Bone defects are often caused by trauma or surgery and can lead to delayed healing or
even bone nonunion, thereby resulting in impaired function of the damaged site. Magnesium …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a
range of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. Multiple …

Induction of immunogenic cell death (ICD) is a promising strategy for cancer
immunotherapy. Chrysin, which has potential anticancer effects, faces limitations in clinical …