Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …

Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases
characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected …

Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health
problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) …

Background & Aims Hepatocyte cellular dysfunction and death induced by lipids and
macrophage-associated inflammation are characteristics of nonalcoholic steatohepatitis …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Metabolic homeostasis emerges from the complex, multidirectional crosstalk between key
metabolic tissues including adipose tissue, liver, and skeletal muscle. This crosstalk …

A subset of patients with non-alcoholic fatty liver disease develop an inflammatory condition,
termed non-alcoholic steatohepatitis (NASH). NASH is characterised by hepatocellular …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the
liver. The pathophysiological role of EVs is increasingly recognized in liver diseases …